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Topics in Antiviral Medicine ; 30(1 SUPPL):5, 2022.
Article in English | EMBASE | ID: covidwho-1880803

ABSTRACT

Research during the COVID-19 outbreak has followed a pattern: observational data and case series followed by more rigorous randomized-controlled trials. The results of these trials have sometimes been inconsistent. Disparate results have arisen from small sample sizes, small changes in protocols, and relatively small effect sizes. These issues can affect any clinical trial but the differences are magnified by the number of simultaneous studies asking very similar questions and the incredible attention that has been paid to results. Here I will discuss the sources of discrepancies and their importance and how some of these issues could be resolved in the future.

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